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A fix for brittle bones, a cover for the ages, and a viral act of kindness
Good morning, GOOD readers. This Saturday, we have hope in the battle against broken bones, a stunning vista from Cinque Torri, and a Beyoncé cover to melt your whole face off.
Greg Sullivan
September 13, 2025 • Est. Reading Time: 7 minutes
In partnership with
“We meet ourselves time and again in a thousand disguises on the path of life.”
― Carl Jung
In this issue...
Tiny protein, big comeback for brittle bones.
It’s a cruel trick of nature: your bones get brittle just as your balance goes downhill. A recipe for disaster. But scientists at Leipzig University might’ve found a fix, at least for the bone part.
GPR133 is a cellular “switch” that flips bone loss into bone gain. With a new compound called AP503, the team successfully reversed osteoporosis-like symptoms in mice. So, I’ve learned two things. We might have a cure for osteoporosis in the offing, and mice get osteoporosis.
As Mark Wales reports, this might be the closest thing to a bone boost button we’ve ever seen.
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If you thought “Don’t Hurt Yourself” was her heaviest track, you missed this firestorm.
If rumors turn out to be true, Beyoncé’s next album will be an all-out rock-n-roll production. But we don’t have to wait till it drops to get a look at what that might sound like. As Ryan Reed reveals, she’s already dipped her toe in those waters—most memorably with a slow-burning, gospel-drenched cover of Kings of Leon’s Sex on Fire at Glastonbury back in 2011.
Kings of Leon noticed too. "We’re all big Beyoncé fans," drummer Nathan Followill later said. Same, Nathan. Same.
And if you’ve somehow forgotten she’s had rock chops all along, go revisit Don’t Hurt Yourself, her blues-psych firestarter collab with Jack White.
Which genre should Beyoncé conquer next?If the rumors are true, her next project might be all-out rock. But let’s dream bigger... |
And what did we learn?
Check in on Monday for the results of all our weekend polls.
He really sold the role, huh?
From the vault: Back in 2014, a French tourist thought she was feeding a man down on his luck near Grand Central. What she didn’t know? The “homeless man” was actually Richard Gere, fully in character for his movie Time Out of Mind.
Two days later, she opened a newspaper and nearly dropped it: front-page photo, handing her leftovers to one of Hollywood’s biggest stars. “It’s crazy, this story,” she laughed. Crazy, and kind of perfect.
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💬 From the group text…
Saturdays are for dancing, and if you need some inspo, meet Joan McCracken, dance goddess from the golden age of film. What is even happening here?!? Someone switch her to decaf.
Until tomorrow, may your next era be your best era.